Parkinson-dementia syndrome is an atypical variant of progressive supranuclear palsy (PSP), a rare late-onset neurodegenerative disease. It is characterized by various symptoms such as speech and language disorders, limb rigidity, freezing of gait, and early parkinsonism. The disease progresses to include features like postural instability, axial rigidity, and facial immobility. Neuropathologically, it is associated with tau pathology and neuronal loss in specific brain areas, including the temporal cortex, midfrontal cortex, and subthalamic nucleus. The syndrome also presents with cognitive decline, ophthalmoparesis, and pyramidal signs due to neurofibrillary degeneration in the hippocampus, basal ganglia, and brainstem nuclei.