Pick disease is a form of frontotemporal dementia characterized by the presence of Pick bodies and Pick cells in the brain. It is associated with behavioral changes, language difficulties, and memory loss. The disease is pathologically defined by severe atrophy, neuronal loss, and the presence of tau-positive inclusions. Frontotemporal dementia generally presents as a behavioral or language disorder with gradual onset, affecting both men and women equally. There is currently no cure for Pick disease, and treatment options are limited to off-label drugs and behavioral interventions. Brain atrophy, specifically in the frontal and temporal lobes, is a common feature of Pick disease and other brain disorders.