Autosomal dominant distal hereditary motor neuronopathy-13 (HMND13) is a neurologic disorder characterized by distal muscle weakness and atrophy affecting both the upper and lower limbs, leading to difficulty walking and poor fine hand motor skills. Some patients may exhibit spasticity and hyperreflexia, particularly in the lower limbs. This disorder overlaps with Silver syndrome and Charcot-Marie-Tooth type 2 (CMT2) due to mutations in the BSCL2 gene on chromosome 11q12. Variability in symptoms can be observed even within the same family, with features ranging from distal sensory impairment to axonal sensorimotor peripheral neuropathy. HMND13 inheritance is autosomal dominant with incomplete penetrance.