Familial hypercholesterolemia-3 (FHCL3) is an autosomal dominant disorder characterized by elevated low-density lipoprotein (LDL) cholesterol levels, leading to xanthelasma, xanthomas, accelerated atherosclerosis, and increased risk of premature coronary heart disease. It is a genetic disorder with high cholesterol levels, particularly high LDL levels, and early cardiovascular disease. FHCL3 is associated with a selective increase in LDL particles in plasma, resulting in tendon and skin xanthomas, arcus corneae, and coronary artery disease. The disorder is inherited in an autosomal dominant manner. Varret et al. (1999) described a French family with hypercholesterolemia, while Haddad et al. (1999) reported a Utah kindred with similar characteristics. FHCL3 is a form of hypercholesterolemia, a condition characterized by high cholesterol levels in the blood, which can lead to various health complications related to lipid metabolism.