Frontotemporal dementia and/or amyotrophic lateral sclerosis-7 (FTDALS7) is an autosomal dominant neurodegenerative disorder characterized by onset of ALS or FTD in adulthood. Patients may exhibit muscle weakness, wasting, bulbar signs, respiratory insufficiency, behavioral changes, memory loss, cognitive decline, and disinhibition. Pathology shows UBB, p62/sequestosome, and TDP43-immunoreactive intraneuronal inclusions. FTD involves frontal and temporal lobe atrophy with neuronal loss, gliosis, and dementia. ALS is characterized by motor neuron death in the brain and spinal cord, leading to paralysis. FTDALS7 can manifest as both ALS and FTD. ALS, also known as Lou Gehrig's disease, affects motor neurons causing muscle problems, speech difficulties, and respiratory failure. FTD is a group of disorders involving behavioral changes, executive dysfunction, and language impairment due to brain degeneration. Familial ALS (FALS) constitutes 5-10% of cases and may involve mutations in the C9ORF72 and SOD1 genes. ALS-PDC is a rare form of ALS with parkinsonism and dementia. FTD can present with personality changes, language deficits, or movement-related issues. Onset of FTD is insidious with a gradual decline in behavior or language. ALS is progressive with muscle twitching, cramps, weakness, and eventual loss of voluntary muscle control. Diagnosis is based on symptoms and tests to rule out other diseases. No cure exists, but medications can manage symptoms and prolong survival.