Familial cold autoinflammatory syndrome-3 is an autosomal dominant immune disorder characterized by cutaneous urticaria, erythema, and pruritus in response to cold exposure. Additional immunologic defects may include antibody deficiency, decreased B cells, defective B cells, increased infection susceptibility, and autoimmune disorder risk. The syndrome is associated with PLCG2 gene deletions on chromosome 16q. Symptoms include cold-induced hives, recurrent infections, autoimmune diseases, and allergic reactions. Cold urticaria typically occurs with evaporative cooling, not contact with cold objects. Other manifestations may include a blistering rash, granulomas, and reduced immune function with lower antibody levels. Autoimmune disorders like thyroiditis and vitiligo can also develop, along with the presence of abnormal antibodies in the blood.